Associate Professor Dr Yap Wei Hsum


Academic Qualification

  • Doctor of Philosophy (Science), UNIVERSITY TUNKU ABDUL RAHAMAN, Malaysia
  • Bachelor of Science (Hons) in Biotechnology, UNIVERSITI TUNKU ABDUL RAHMAN, Malaysia

Professional Qualification

  • PGCHeTL, TAYLOR'S UNIVERSITY, Malaysia

Areas of Expertise

  • Medical And Health Sciences, Pharmacology, Molecular Pharmacology

Research Interest

  • Macrophage foam cells
  • Skin models

Publications

2024
  • In vivo Retinoid Metabolic and Visual Cycle Pathways Assessment of Carotenoid-Rich Refined Red Palm-Pressed Mesocarp Olein (ISI-Indexed), Journal of Functional Foods - Article in Journals
  • Black soldier fly (Hermetia illucens L.): A potential small mighty giant in the field of cosmeceuticals (ISI-Indexed), Health Science Reports - Article in Journals
  • The senescent marker p16INK4a enhances macrophage foam cells formation (ISI-Indexed), Molecular Biology Reports - Article in Journals
  • Phage Display Screening in Breast Cancer: From Peptide Discovery to Clinical Applications (ISI-Indexed), Life Sciences - Article in Journals
  • Nrf2 Connects Cellular Autophagy and Vascular Senescence in Atherosclerosis: A Mini-Review (SCOPUS-Indexed), Journal of Lipid and Atherosclerosis - Article in Journals
2023
  • In-Silico Study of Anticancer and Antimicrobial Peptides Derived from Cycloviolacin O2 (CyO2) (ISI-Indexed), In-Silico Study of Anticancer and Antimicrobial Peptides Derived from Cycloviolacin O2 (CyO2) - Article in Journals
  • Hydroxychloroquine: Key therapeutic advances and emerging nanotechnological landscape for cancer mitigation (ISI-Indexed), CHEMICO-BIOLOGICAL INTERACTIONS - Article in Journals
  • Editorial: Biofunctional Molecule Exploratory Research on Application in Food and Health (ISI-Indexed), MOLECULES - Article in Journals
2022
  • Targeting Immune Senescence in Atherosclerosis (ISI-Indexed), International Journal of Molecular Sciences - Article in Journals
  • Network Analysis in the Identification of Genes Conferring Metastatic Potential in Hepatocellular Carcinoma (ISI-Indexed), Eurasian Journal of Medicine and Oncology - Article in Journals
  • Knowledge transfer of eLearning objects: Lessons learned from an intercontinental capacity building project (ISI-Indexed), Plos One - Article in Journals
  • Editorial: The genetics of human Mendelian skin disorders (ISI-Indexed), frontiers in genetics - Article in Journals
  • Integrated Assessment of Macrophage Lipids Homeostasis Omics Data: Identification of Potential Genes and Pathways in Atherosclerosis (SCOPUS-Indexed), Progress in Drug Discovery & Biomedical Science - Article in Journals
2021
  • Participatory Approach in Reusable Learning Object (RLO) Development Using ASPIRE Framework: Taylor's University's Experience - Book Chapter
  • An Overview of the Bioactivities of Gedunin - Book Chapter
  • In vitro evaluation of the involvement of Nrf2 in maslinic acid-mediated anti-inflammatory effects in atheroma pathogenesis (ISI-Indexed), LIFE SCIENCES - Article in Journals
  • Prioritising topics for developing e-learning resources in healthcare curricula: A comparison between students and educators using a modified Delphi survey (ISI-Indexed), Plos One - Article in Journals
  • Biological Activities of Snowdrop (Galanthus spp., Family Amaryllidaceae) (ISI-Indexed), Frontiers in Pharmacology - Article in Journals
2020
  • Anticancer Mechanisms of Bioactive Peptides (ISI-Indexed), Protein & Peptide Letters - Article in Journals
  • Angelicin A Furocoumarin Compound With Vast Biological Potential (ISI-Indexed), FRONTIERS IN PHARMACOLOGY - Article in Journals
  • Hyaluronic Acid-Mediated Drug Delivery System Targeting for Inflammatory Skin Diseases: A Mini Review (ISI-Indexed), FRONTIERS IN PHARMACOLOGY - Article in Journals
  • Maslinic acid suppresses macrophage foam cells formation: Regulation of monocyte recruitment and macrophage lipids homeostasis (ISI-Indexed), Vascular Pharmacology - Article in Journals
  • Microalgae as Potential Anti-inflammatory Natural Product against Human Inflammatory Skin Diseases (ISI-Indexed), Frontiers in Pharmacology - Article in Journals
2019
  • Combining Understanding of Immunological Mechanisms and Genetic Variants Toward Development of Personalized Medicine for Psoriasis Patients (ISI-Indexed), Frontiers in Genetics - Article in Journals
  • An Optimized Cosmetic Screening Assay for Ultraviolet B (UVB) Protec-tive Property of Natural Products, Progress in Drug Discovery & Biomedical Science - Article in Journals
  • Formononetin: A Review of Its Anticancer Potentials and Mechanisms (ISI-Indexed), FRONTIERS IN PHARMACOLOGY - Article in Journals
  • Bioactivity evaluation of bio-hydroxyapatite derived from Spanish mackerel in composite scaffolds for bone tissue engineering (ISI-Indexed) - Article in Proceeding
  • Model of Experimentation for Photoprotective Properties of Natural Products Against Ultraviolet C (UVC) Damage: A Case Study On Rosmarinic Acid, Progress in Drug Discovery & Biomedical Science - Article in Journals
2018
  • A reliable and affordable 3D tumor spheroid model for natural product drug discovery: a case study of curcumin, Progress in Drug Discovery & Biomedical Science - Article in Journals
  • Maslinic acid suppresses macrophage foam cell formation via inhibition of LDL oxidation and cholesterol efflux (ISI-Indexed) - Article in Proceeding
  • Maslinic acid modulates secreted phospholipase A2-IIA (sPLA2-IIA)-mediated inflammatory effects in macrophage foam cells formation (ISI-Indexed), Journal of Biosciences - Article in Journals
  • Differential effects of sPLA2-GV and GX on cellular proliferation and lipid accumulation in HT29 colon cancer cells (ISI-Indexed), Molecular and Cellular Biochemistry - Article in Journals
  • Resveratrol Potential Antibacterial Agent against Foodborne Pathogens (ISI-Indexed), FRONTIERS IN PHARMACOLOGY - Article in Journals
2017
  • Oxidative Stress in Cardiovascular Diseases: Involvement of Nrf2 Antioxidant Redox Signaling in Macrophage Foam Cells Formation (ISI-Indexed), International Journal of Molecular Sciences - Article in Journals
2016
  • Inhibition of Human Group IIA-Secreted Phospholipase A2 and THP-1 Monocyte Recruitment by Maslinic Acid. Lipids (ISI-Indexed), Lipids - Article in Journals
2015
  • Mechanistic Perspectives of Maslinic Acid in Targeting Inflammation (ISI-Indexed), Biochemistry Research International - Article in Journals

Research

  • Investigating Bioactive Anticancer Peptides from Scorpion Venom: Targeting Diverse Breast Cancer Cell Types ,  Co-researcher2023 to 2025, Taylor's University
  • New vaccination technology via skin absorption: Elucidation of skin penetration and immunogenicity profiles of an antigen model,  Co-researcher2022 to 2025, National
  • Curcumin analogues with N-methyl 4-piperidone linker suppress immune functions and MyD88-dependent NF-kB/MAPKs/ PI3-Akt signaling pathways in LPS-primed macrophages,  Co-researcher2020 to 2024, National
  • Identification and evaluation of diagnostic tumour-homing peptides specifically targeting metastatic breast cancer cells using phage-displayed peptide libraries,  Co-researcher2020 to 2024, National
  • Unraveling the role of cellular senescence marker p16INK4a in atherosclerotic lesion fatty streaks foam cells formation,  Project Leader2019 to 2023, National
  • Antioxidative potential amphiphile-modified low molecular weight hyaluronic acid (LMWHA) loaded with kojic acid ester (KAE) nanoemulsion,  Co-researcher2019 to 2022, National
  • Investigating the Modulatory Effects of Swietenia Macrophylla Seed Extracts and Limonoid Compounds in Regulating Macrophage Cholesterol Homeostasis ,  Project Leader2018 to 2020, Taylor's University
  • In vitro evaluation of polar and tropical microalgae extracts as anti-oxidative and de-pigmenting agents in cosmeceutical products,  Co-researcher2018 to 2020, Taylor's University
  • In silico prediction and in vitro validation of mauriporin-derived peptides as potential therapeutic anticancer agents,  Co-researcher2018 to 2019, Taylor's University
  • Preparation and characterisation of polyvinyl alcohol with natural hydroxyapatite from fish bone as biocomposite nanomaterial,  Co-researcher2018 to 2020, Taylor's University

Awards and Stewardship

  • International Union of Biochemistry and Molecular Biology Travel Fellowship, Conference, International Union of Biochemistry and Molecular Biology (IUBMB), Fellowship , 2024
  • International University Carnival on E-Learning (IUCEL 2022), Competition, Ministry of Higher Education, Gold award , 2022
  • The Virtual International e-Content Development Competition 2021, Competition, Ministry of Higher Education, Gold Award , 2021
  • Outstanding Open Educational Resources (OER) Award, Competition, Ministry of Higher Education, Outstanding Open Educational Resources (OER) Award , 2021
  • FAOBMB Education Special Travel Fellowship 2021, Conference, Federation of National Societies of Biochemistry and Molecular Biology (FAOBMB), Australia, Fellowship , 2021
  • International e-Learning Carnival & Conference Gold Award, Conference, Ministry of Higher Education, Best Presentation , 2019
  • International University Carnival on eLearning Bronze Award, Conference, Ministry of Higher Education, Best Presentation , 2018
  • Putra InnoCreative Carnival in Teaching and Learning 2018 Silver Award, Conference, Universiti Putra Malaysia (UPM), Best Presentation , 2018
  • Elsevier Reviewer Recognition (Biomedicine and Pharmacotherapy), Services, Elsevier, Journal Reviewer Award , 2017
  • SPARK award, Competition, Taylor's University, Creativity , 2016

Paper Presented

  • Leveraging Reusable Learning Objects for Digital Sustainability in Higher Education, 2024 Inter-regional Research Symposium [20-22 November 2024] (Symposium), ORAL PRESENTER , 20/11/2024 to 22/11/2024
  • Beyond the Pill: Personalized Medicine and the Future of Biotherapeutics, Faculty Development Program on Frontiers in Drug Discovery: Advancements and Innovations in the Drug Development Process, 2024 (Course), PLEANARY/KEYNOTE SPEAKER , 21/10/2024 to 25/10/2024
  • Targeting Foam Cell Formation in Atherosclerosis: From Molecular Mechanisms to Therapeutic Interventions, 4th International Conference of Pharmacy (ICP 2024) (CONFERENCE), PLEANARY/KEYNOTE SPEAKER , 18/10/2024 to 19/10/2024
  • Empowering Future-Ready Graduates with Competency-Based Learning at Taylor s University, 48th Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology (IM-MSBMB48) (CONFERENCE), ORAL PRESENTER , 14/08/2024 to 15/08/2024
  • Identifying The Role Of Oxidative Stress And Senescence In Regulating Foam Cells Formation, Sunway Early-Career Researchers (ECR) - Postgraduates (PG) Mini Research Symposium (Symposium), INVITED SPEAKER , 04/07/2024 to 05/07/2024
  • Virtual laboratory simulation enhances psychomotor skills through reflective learning, Federation of European Biochemical Society (FEBS) Education and Training Conference 2024 (CONFERENCE), ORAL PRESENTER , 20/03/2024 to 23/03/2024
  • ASSESSING CRITICAL THINKING USING LABORATORY DATA-GENERATORS: A CASE STUDY ON CLONING OF CRISPR CONSTRUCT, International University Carnival on E-Learning (CONFERENCE), ORAL PRESENTER , 28/06/2022 to 30/06/2022
  • Fireside chat: Assessing Laboratory in an online environment: Can it be done? (Higher education: digital assessment) , Edutech Asia: Inspiring the next generation across Asia (SEMINAR), INVITED SPEAKER , 09/11/2021 to 11/11/2021
  • Foam cell formation: Targeting macrophage lipids homeostasis and inflammation in atherosclerosis, Graduate Research Symposium 2021 (CONFERENCE), PLEANARY/KEYNOTE SPEAKER , 30/11/2021 to 30/11/2021
  • Secretory Phospholipase A2-IIA-regulation of macrophage lipid accumulation by Maslinic acid a potent anti-inflammatory molecule, 43rd PSBMB Annual Convention (CONFERENCE), ORAL PRESENTER , 05/12/2016 to 07/12/2016